Gabapentin Increases Analgesic Effect of Chronic Use of Morphine while Decreases Withdrawal Signs
نویسندگان
چکیده
منابع مشابه
Gabapentin increases analgesic effect of morphine in male rats
The clinical usefulness of morphine for treatment of chronic pain is limited by development of tolerance. So many authors have proposed the co-administration of other drugs. This study was performed to evaluate the role of gabapentin on analgesic effect of morphine. Four groups of male rats (220-250 g) were examined for time latency using tail flick test: control, morphine (M), gabapentin (GB),...
متن کاملGabapentin increases analgesic effect of morphine in male rats
The clinical usefulness of morphine for treatment of chronic pain is limited by development of tolerance. So many authors have proposed the co-administration of other drugs. This study was performed to evaluate the role of gabapentin on analgesic effect of morphine. Four groups of male rats (220-250 g) were examined for time latency using tail flick test: control, morphine (M), gabapentin (GB),...
متن کاملThe effect of gabapentin on the withdrawal signs in morphine-dependent male rats
Acute morphine withdrawal is considered to be the physical manifestation of dependence, emerging when morphine administration is stopped or after the administration of an opiate antagonist, such as naloxone. Gabapentin, which is an antiepileptic, agent, enhances the analgesic effect of morphine in healthy volunteers, but its effect on morphine dependence and withdrawal signs has not determined ...
متن کاملThe effect of gabapentin on the withdrawal signs in morphine-dependent male rats
Acute morphine withdrawal is considered to be the physical manifestation of dependence, emerging when morphine administration is stopped or after the administration of an opiate antagonist, such as naloxone. Gabapentin, which is an antiepileptic, agent, enhances the analgesic effect of morphine in healthy volunteers, but its effect on morphine dependence and withdrawal signs has not determined ...
متن کاملGabapentin enhances the analgesic effect of morphine in healthy volunteers.
UNLABELLED The most effective group of drugs for the treatment of severe pain is opioid analgesics. Their use, however, is limited by decreased effects in neuropathic and chronic pain as a result of increased pain and development of tolerance. Gabapentin (GBP) is effective in both experimental models of chronic pain and clinical studies of neuropathic pain. Therefore, we investigated, in a rand...
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ژورنال
عنوان ژورنال: International Journal of Pharmacology
سال: 2005
ISSN: 1811-7775
DOI: 10.3923/ijp.2005.161.166